Andre Esterhuizen will start at 12 with Damian de Allende shifting to 13. Jasper Wiese is back at 8 with Franco Mostert moving to 7. Marvin Orie and Salmaan Moerat will be the starting locks with Eben Etzebeth moving to the bench. Evan Roos should get his second Bok cap later in the game.
Italy has beaten both Wales and Australia this year. The Boks will have to be fully ready mentally for this game – otherwise Italy will add another big name scalp.
The biggest issue for the Boks is the execution of their exits. With Andre that can kick the ball for miles adding another option hopefully this can be fixed.
15 Willie le Roux, 14 Cheslin Kolbe, 13 Damian de Allende, 12 Andre Esterhuizen, 11 Kurt-Lee Arendse, 10 Damian Willemse, 9 Faf de Klerk, 8 Jasper Wiese, 7 Franco Mostert, 6 Siya Kolisi (c), 5 Marvin Orie, 4 Salmaan Moerat, 3 Frans Malherbe, 2 Bongi Mbonambi, 1 Ox Nche.
Subs: 16 Malcolm Marx, 17 Steven Kitshoff, 18 Vincent Koch, 19 Eben Etzebeth, 20 Kwagga Smith, 21 Evan Roos, 22 Cobus Reinach, 23 Manie Libbok.